Domperidone (Motilium): Uses, Side Effects, Dosage, Interactions – Fastest way to lose 20 pounds


Domperidone (brand name: Motilium) is a dopamine receptor blocker that accelerates gastrointestinal peristalsis, causes the release of prolactin and is used as an antiemetic.

Domperidone is a medicine that can be used to stop nausea and vomiting and to treat stomach aches in some cases.

If you have problems with breastfeeding but do not want other options, such as medication or surgery (which may cause additional complications), your doctor may prescribe domperidone for an increased amount of milk.

Domperidone is only available by prescription because of potential side effects, such as dry mouth if taken regularly.

You will need to take it three times a day before meals (which works best), but people usually take it when they need it.

Domperidone is available in the following dosage forms:

Motilium tablets
Motilium tablets
Motilium syrup
Motilium syrup

Motilium (Domperidone) Uses

Let’s take a look at some of the common uses of domperidone.

  • Motilium is a medicine that increases the movements or contractions of the stomach and intestines.
  • Domperidone is additionally used to treat nausea and vomiting caused by other medicines.
  • It is used to treat Parkinson’s disease, such as levodopa, pramipexole and apomorphine.
  • It is used in the treatment of gastroesophageal reflux disease (GERD).
  • Motilium can also be used in epigastric pain.
  • It can also be used to treat dyspepsia and heartburn.

Motilium’s mechanism of action

  • Motilium works by blocking chemicals in the brain and gut. This results in improved movement and faster gastric emptying, which helps prevent vomiting.
  • Domperidone is associated with its activity of obstructing dopaminergic receptors in both the receptor and the gastric triggering site. has robust affinities for dopamine D2 and D3 receptors found in the trigger area of ​​chemoreceptors placed simply outside the blood-brain barrier, which – among other things – regulate nausea and vomiting.

Dosage of domperidone – How to use

Take this medicine orally, as it is usually prescribed 30 minutes before eating and at bedtime. Do not increase your dose or take it more often than not. Your condition does not improve faster, but the risk of side effects increases.

There are two dosage forms of domperidone.

One is a tablet and the other is a liquid dosage form.

So you need to take the whole tablet without crushing or chewing it. The usual recommended dose of Motilium 10 mg tablet is three times a day, and the maximum daily dose is 30 mg.

While in the case of the liquid dosage form, you will need to take 1-2 full tablespoons three times a day, or your pharmacist will optimize your dose according to your needs.

You may forget to take domperidone. If this happens, it is best not to skip any dose and take the next one at the usual time. Do not duplicate medications; this could cause side effects such as stomach cramps or headaches.

However, there are some risks associated with taking too much domperidone, which include: many people will experience, after consuming more than the prescribed dose, could lead to either a dangerous and irregular heartbeat.

The duration of therapy is one week, and the maximum treatment should not exceed seven days.


Motilium Side Effects

Domperidone (Motilium) side effects include;

  • Abdominal cramps,
  • Dry mouth,
  • Diarrhea,
  • Nausea,
  • Eczema,
  • Itching,
  • Hives,
  • Breast enlargement,
  • galactoree,
  • Breast pain / tenderness,
  • hypogonadism,
  • Gynecomastia and
  • menstrual irregularities).

Other uncommon side effects include

  • insomnia,
  • Sleepiness,
  • Akatisia,
  • Restlessness,
  • Fatigue,
  • Fatigue,
  • Extrapyramidal symptoms,
  • dystonia,
  • Parkinson’s symptoms,
  • Late dyskinesia and
  • Depression.

Motilium contraindications

Domperidone is contraindicated in the following situations:

  • It is not recommended if you have a known hypersensitivity to domperidone or to any of the excipients in Motilium or any other brand.
  • In patients with moderate to severe hepatic impairment.
  • Concomitant use with potent CY3A4 inhibitors (regardless of its effect of prolonging the QT interval)
  • It is already known that patients prolong the intervals of cardiac conduction, especially QTc, patients with significant electrolyte imbalance or heart disease such as heart failure.
  • A pituitary tumor that releases prolactin (prolactinoma)
  • Tell your doctor if you have problems with your kidneys, liver and heart.
  • It must not be used in gastrointestinal bleeding, mechanical obstruction or perforation.
  • Tablets contain lactose and may not be suitable for patients with lactose intolerance, galactosemia or glucose / galactose malabsorption.
  • Motilium should be used with caution in children over 60 years of age.

Use of domperidone (Motilium) during pregnancy

The safety of this medicine during pregnancy has not been established. Therefore, it should not be used in pregnant women unless the potential benefits to the mother outweigh any risks to the developing child.

It should only be used if the medicine is considered essential by your doctor. Ask your doctor for any recommendations.

Motilium interactions with other medicines

As it improves movement in the digestive tract, it can affect the absorption and effects of other drugs. Therefore, it is essential that you tell your doctor about any over-the-counter or prescription medications that you may be taking, including:

  • MAOIs (eg furazolidone, phenelzine, selegilinetranilcipromin).
  • Concomitant use of Motilium with Ketoconazole or any other azole derivative increases the level and causes cardiovascular side effects.
  • Avoid concomitant use of antiarrhythmics, some fluoroquinolones, antipsychotics, beta-2 adrenergic agonists, antimalarials, SSRIs, tri / tetracyclic antidepressants and nefazodone with Motilium, as it increases the risk of cardiovascular disease.
  • Do not start or stop medicines without the approval of your doctor or pharmacist.

Motilium dosing information

  • Take this medicine by mouth, as prescribed, usually half an hour before meals and during the day.
  • The dose for adults and young people over the age of 16 is 10 mg (one tablet) up to three times a day. Do not take more than three doses in any 24 hours.
  • If it was prescribed for a small child, the dose will be printed on the package label to remind you of what the doctor said.
  • Do not increase the dose and do not take it more often than recommended. Your condition will not improve faster, but the chances of side effects will increase.

How is Motilium stored?

Storage at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat and light. Do not store in the bathroom.


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